Expression pattern of macrophage migration inhibitory factor during embryogenesis

Expression pattern of macrophage migration inhibitory factor during embryogenesis

Although macrophage migration inhibitory factor (MIF) was originally identified as a lymphokine that inhibits the migration of macrophages, its ubiquitous expression suggests it may have a role beyond the immune system. Here we report a detailed characterization of MIF expression during mouse embryogenesis. The MIF expression pattern was found to parallel tissues specification and organogenesis.

Macrophage Migration Inhibitory Factor

I-43: Expression Profile of Macrophage Migration Inhibitory Factor (MIF) Signaling Pathway as A Potentional Biomarker in Pathophysiology of Endometriosis

Background MIF via its receptor, CD74, initiates a signaling cascade that leads to proliferation and survival of cells. Also, MIF binding to CD74 activates p38 signaling pathways that lead to positive effect on the expression of COX-2. The aim of this study was to evaluate the gene expression profile of MIF, CD74 and COX-2 in normal, ectopic and eutopic endometrium during menstrual cycle. The e...

O-28: Endometriosis Is Influenced by The Promoter Haplotype-Based Expression of Macrophage Migration Inhibitory Factor (MIF)

Background: Macrophage migration inhibitory factor (MIF) is a key pro-inflammatory cytokine that is secreted by accumulated active macrophages in ectopic tissue of endometriosis. MIF is involved in pathophysiological events of endometriosis, such as angiogenesis and cell proliferation. MIF that stimulates the synthesis of PGE2, leads to over-expression of local estradiol synthesis in endometrio...

The expression of macrophage migration inhibitory factor in adenomyosis

The aim of the present study was to investigate whether the expression of macrophage migration inhibitory factor (MIF) is altered in eutopic endometrium and ectopic lesion of women with adenomyosis. MIF expression was assessed by immunohistochemistry, western blotting analysis. Elevated expression of MIF protein was seen in eutopic endometrium and ectopic lesion of women with adenomyosis (P<0.0...